Remission of a paraneoplastic cerebellar syndrome. (1985 Oct)
remission of a paraneoplastic cerebellar syndrome . A case history is reported of spontaneous improvement of a sub acute paraneoplastic cerebellar syndrome , that is before treatment of the primary ( lung ) tumour .

Paraneoplastic optic neuropathy and autoantibody production in small cell carcinoma of the lung. (1998 Nov)
paraneoplastic optic neuropathy and autoantibody production in small cell carcinoma of the lung . A 59 year old woman presented with acute onset , bilateral , painless loss of vision , dysarthria , and ataxia . ophthalmoscopy showed bilateral optic disc edema . A magnetic resonance scan of the head was normal . chest radiography showed mediastinal adenopathy . mediastinoscopy and biopsy identified small cell carcinoma of the lung . An autoantibody to optic nerve and retina was demonstrated in the patient s serum . An electroretinogram was normal . The patient was diagnosed with a paraneoplastic optic neuropathy and paraneoplastic cerebellar syndrome . after treatment for her lung cancer , the patient remains stable from a visual and neurologic standpoint .

Thoughts on a supposedly paraneoplastic cerebellar syndrome (2000 Jun)
thoughts on a supposedly paraneoplastic cerebellar syndrome

Paraneoplastic cerebellar syndrome and optic neuritis with anti CV2 antibodies : clinical response to excision of the primary tumor. (1998 Apr)
paraneoplastic cerebellar syndrome and optic neuritis with anti CV2 antibodies : clinical response to excision of the primary tumor . objective : To describe a patient with a paraneoplastic cerebellar syndrome and optic neuritis with circulating anti CV2 antibodies and clinical improvement after excision of a small cell lung carcinoma . design : report of a case . setting : A 62 year old man simultaneously developed a severe cerebellar syndrome and a bilateral optic neuritis predominantly in the left eye ( visual acuity , 20 / 25 in the right eye ; 20 / 400 in the left eye ; and bilateral swelling of the optic discs ) . MAIN outcome AND results : Anti CV2 antibodies , recently described as associated with paraneoplastic neurological syndrome , were detected in the patient s serum sample . these antibodies were demonstrated to react with the cytoplasm of a subpopulation of oligodendrocytes in the white matter of rat brain in the cerebellum , brainstem , spinal cord , and optic chiasm . The patient was found to have a small cell lung carcinoma , which was removed . after excision of the tumor , the cerebellar syndrome improved dramatically and the papilledema disappeared despite aftereffects of the optic neuritis . conclusions : these findings were consistent with the diagnosis of a paraneoplastic neurological syndrome , although both optic neuritis and remission of the cerebellar syndrome are uncommon patterns of paraneoplastic syndromes . CV2 antigen expression by the oligodendrocytes of the cerebellum …

A patient with breast cancer and paraneoplastic cerebellar syndrome associated with anti purkinje cell antibodies : response to CMF chemotherapy. (1998 Oct)
A patient with breast cancer and paraneoplastic cerebellar syndrome associated with anti purkinje cell antibodies : response to CMF chemotherapy . A 41 year old lady underwent a left mastectomy and axillary clearance in 1992 , for T2N0 breast cancer . She remained well until december 1995 , when she presented with a rapidly progressive cerebellar ataxia . Full investigations for metastatic disease were negative . A clinical diagnosis of paraneoplastic cerebellar degeneration was confirmed by a high titre of anti purkinje cell antibodies . She was treated with cyclophosphomide , methotrexate and 5 fluorouracil . The improvement in neurological symptoms was dramatic and has been maintained by further hormone manipulation ( ovarian ablation ) . The patient now leads a normal life without medication .

Relapsing paraneoplastic cerebellar syndrome and limbic encephalitis in a patient with breast cancer paraneoplastic neurological syndromes are rare diseases that … (2000 Jun)
relapsing paraneoplastic cerebellar syndrome and limbic encephalitis in a patient with breast cancer paraneoplastic neurological syndromes are rare diseases that occur in relation to cancer . supporting the hypothesis of an autoimmune mechanism , specific antineuronal antibodies have sometimes been detected . The current possibilities for treatment are limited . A female patient , aged 57 , suffering from a breast cancer , developed a severe paraneoplastic cerebellar syndrome and limbic encephalitis within a few weeks . It is possible that the impressive partial remission that occurred during the ensuing 6 months was not due to therapy . although the patient was still bound to a wheelchair , discharge from hospital was possible because she was still able to perform daily tasks by herself . A recurrence of the cerebellar symptoms with mild alterations of mental status occurred 2 months later but again showed a good remission .

A supposedly paraneoplastic cerebellar syndrome (2000 Aug)
A supposedly paraneoplastic cerebellar syndrome

Reversal of subacute paraneoplastic cerebellar syndrome with intravenous immunoglobulin. (1994 Jul)
reversal of subacute paraneoplastic cerebellar syndrome with intravenous immunoglobulin .

Association of antineural autoantibodies in a patient with paraneoplastic cerebellar syndrome and small cell lung carcinoma. (1997 Apr)
association of antineural autoantibodies in a patient with paraneoplastic cerebellar syndrome and small cell lung carcinoma .